Classic textbook neurology teaches that amyotrophic lateral sclerosis (ALS) is a
degenerative disease that selectively affects upper and lower motor neurons and is fatal 3–5 …

Increased awareness of cognitive and behavioural change in amyotrophic lateral sclerosis
has been driven by various clinic-based and population-based studies. A frontotemporal …

Background Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor
neuron disease with a variable natural history. There are no accurate models that predict the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a substantial
heritable component. In pedigrees affected by its familial form, incomplete penetrance is …

C9orf72 hexanucleotide repeat expansions are the most common cause of familial
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) worldwide. The …

We examined the phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) inclusions
as well as neuronal loss in full-length spinal cords and five selected regions of the central …

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Objective The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis
(ALS) by comparing patterns of neurodegeneration using brain magnetic resonance …

Abstract The GGGGCC (G 4 C 2) repeat expansion in C9ORF72 is the most common cause
of familial amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD) and …

How do C9ORF72 repeat expansions cause amyotrophic lateral s... : Current Opinion in
Neurology How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and …