Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge,,,–
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …

Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …

Conclusions: This study indicates that DOCK2 controls CD8+ T-cell infiltration in HCC, and
cholesterol sulfate synthesized by sulfotransferase 2B1 in tumor cells promotes effector T …

Tissue-resident CD8+ T cells (TRM) continuously scan peptide-MHC (pMHC) complexes in
their organ of residence to intercept microbial invaders. Recent data showed that TRM …

Progression of solid tumors to the metastatic stage is accountable for the majority of cancer-
related deaths. Further understanding of the molecular mechanisms governing metastasis is …

Oncogenic Ras plays a key role in cancer initiation but also contributes to malignant
phenotypes by stimulating nutrient uptake and promoting invasive migration. Because these …