Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

Advances and gaps in SARS-CoV-2 infection models

C Muñoz-Fontela, L Widerspick, RA Albrecht… - PLoS …, 2022 - journals.plos.org
The global response to Coronavirus Disease 2019 (COVID-19) is now facing new
challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern …

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

F Armando, G Beythien, FK Kaiser, L Allnoch… - Nature …, 2022 - nature.com
Since its discovery in 2019, multiple variants of severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) have been identified. This study investigates virus spread and …

Vaccine-associated enhanced disease and pathogenic human coronaviruses

C Gartlan, T Tipton, FJ Salguero, Q Sattentau… - Frontiers in …, 2022 - frontiersin.org
Vaccine-associated enhanced disease (VAED) is a difficult phenomenon to define and can
be confused with vaccine failure. Using studies on respiratory syncytial virus (RSV) …

Protective roles and protective mechanisms of neutralizing antibodies against SARS-CoV-2 infection and their potential clinical implications

EC Abebe, TA Dejenie - Frontiers in Immunology, 2023 - frontiersin.org
Neutralizing antibodies (NAbs) are central players in the humoral immunity that defends the
body from SARS-CoV-2 infection by blocking viral entry into host cells and neutralizing their …

Vaccine-associated enhanced disease in humans and animal models: Lessons and challenges for vaccine development

J Bigay, R Le Grand, F Martinon… - Frontiers in …, 2022 - frontiersin.org
The fight against infectious diseases calls for the development of safe and effective vaccines
that generate long-lasting protective immunity. In a few situations, vaccine-mediated immune …

Influence of aerosol delivered BCG vaccination on immunological and disease parameters following SARS-CoV-2 challenge in rhesus macaques

AD White, L Sibley, C Sarfas, AL Morrison… - Frontiers in …, 2022 - frontiersin.org
The tuberculosis vaccine, Bacille Calmette-Guerin (BCG), also affords protection against
non-tuberculous diseases attributable to heterologous immune mechanisms such as trained …

Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

MA Stammes, JH Lee, L Meijer, T Naninck… - Trends in Molecular …, 2022 - cell.com
Chest X-ray (CXR), computed tomography (CT), and positron emission tomography–
computed tomography (PET-CT) are noninvasive imaging techniques widely used in human …

Engineering self-assembled endolysin nanoparticles against antibiotic-resistant bacteria

CKO Dzuvor, BK Shanbhag, T Younas… - ACS Applied Bio …, 2022 - ACS Publications
Antibiotic resistance represents a serious global health concern and has stimulated the
development of antimicrobial nanomaterials to combat resistant bacteria. Protein-based …

Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species

AC Fears, BJ Beddingfield, NR Chirichella… - PLoS …, 2022 - journals.plos.org
The novel coronavirus SARS-CoV-2 emerged in late 2019, rapidly reached pandemic
status, and has maintained global ubiquity through the emergence of variants of concern …