The search for new, effective, and low-toxic anticancer agents is one of the most important
tasks of modern medicinal chemistry. In general, the solution to this problem comes down to …

Eukaryotic topoisomerase I (Top1) is a monomeric enzyme that catalyzes the relaxation of
supercoiled DNA during important processes including DNA replication, transcription …

New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit
potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human …

The topoisomerase-I (topo-I) inhibitor topotecan, derivative of camptothecin, is the only
registered drug for relapsed small cell lung cancer (SCLC). The histone deacetylase …

Simple Summary Currently, the whole world is acutely concerned with the selection of
effective treatment regimens for oncological diseases. This problem is becoming more and …

The novel fatty acids (2 R, 5 Z, 9 Z)-2-methoxy-25-methyl-5, 9-hexacosadienoic acid (1a)
and (2 R, 5 Z, 9 Z)-2-methoxy-24-methyl-5, 9-hexacosadienoic acid (1b) were isolated in …

The ability of oxindolimine copper (ii) and zinc (ii) complexes, known to have antitumor
activity, to inhibit human topoisomerase IB has been tested through enzymatic kinetic assays …

Herein we discuss five ruthenium (II) complexes with good cytotoxicity against cancer cells.
These complexes are named [Ru (tzdt)(bipy)(dppb)] PF6 (1),[Ru (mmi)(bipy)(dppb)] PF6 …

Marine compounds are a potential source of new anticancer drugs. In this study, the
antiproliferative effects of 20 invertebrate marine extracts on three colon cancer cell models …

Copper (II) and zinc (II) complexes with oxindolimine ligands, obtained by a condensation
reaction between isatin (1H-indole-2, 3-dione) and 2-(2-aminoethyl) pyridine, have been …