Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

Altered energy metabolism has been implicated both in aging and the pathogenesis of late-
onset Alzheimer's disease (LOAD). However, it is unclear which anomalies are acquired …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

1 Kaiser T, Feng G. Modeling psychiatric disorders for developing effective treatments. Nat
Med 2015; 21: 979–88. 2 Brennand KJ, Simone A, Jou J, et al. Modelling schizophrenia …

Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with
genome-wide significance. However, the functional consequence of these risk alleles is …