Cyclodextrins (CD) and derivatives are functional excipients that can improve the
bioavailability of numerous drugs. Because of their drug solubility improving properties they …

Insulin, a pivotal anabolic hormone, regulates glucose homeostasis by facilitating the
conversion of blood glucose to energy or storage. Dysfunction in insulin activity, often …

Nanoemulsions can be tuned toward enhanced gastro-intestinal retention time by
incorporating thiolated surfactants into their surface. Tailoring the chemical reactivity of the …

This study aimed at designing an S-protected thiolated β-cyclodextrin (β-CD) exhibiting
enhanced mucoadhesive properties. The native β-CD was thiolated with phosphorus …

Bladder cancer is one of the most common clinical malignant tumors with a high recurrence
rate after surgery. To improve the therapeutic effect, intravesical instillation of …

This study aims to compare the potential of Polyethylene glycol (PEG‐free and PEG‐based
self‐emulsifying drug delivery systems (SEDDS) for the oral administration of insulin …

Mucus is a hydrated, viscoelastic, and adhesive gel that lubricates and protects the body
from pathogens; however, its protective function hinders drug/nanomedicine diffusion and …

The present study aims to develop a novel thiolated carboxymethyl cellulose (CMC-SH) by
the addition of aldehyde groups via oxidation followed by reductive amination and then …

Abstract Background and Aim Polyrotaxanes are molecular necklaces composed of
polymers, threaded macrocycles, and bulky stopper molecules to inhibit the decomposition …

Mucoadhesive polymers have received significant interest in drug delivery due to the
prolonged residence time on various mucus gel layers. Not only local effects but also the …