Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative
nuclear factor-κB (NF-κB) signaling in resting cells by targeting NF-κB–inducing kinase (NIK) …

Glucocorticoids have potent anti-inflammatory effects and have been used to treat patients
with rheumatoid arthritis for more than 60 years. However, severe adverse effects of …

Animal and human in vitro models suggest that stress-related B lymphocyte decrements are
due to high levels of glucocorticoids which cause apoptosis of pre-B-cells as they emerge …

Lamprey and hagfish, the living representatives of jawless vertebrates, use genomic leucine-
rich-repeat cassettes for the combinatorial assembly of diverse antigen receptor genes …

Glucocorticoids have an important role in the resolution of inflammation and clinically they
are routinely used to treat allergies, asthma, sepsis, and autoimmune diseases. In addition …

Reelin, an extracellular matrix protein with putative antidepressant-like properties, becomes
dysregulated by chronic stress. Improvement in cognitive dysfunction and depression-like …

Activation of the HPA-axis and SNS are widely accepted to link chronic stress with elevated
levels of peripheral pro-inflammatory markers in blood. Yet, empirical evidence showing that …

One of the human body's initial responses to stress is the adrenal response, involving the
release of mediators that include adrenaline and glucocorticoids (GC). GC are involved in …