Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …

Plant virus nanoparticles (VNPs) are inexpensive to produce, safe, biodegradable and
efficacious as treatments. The applications of r plant virus nanoparticles range from epitope …

Hexahistidine-tagged proteins can be clustered by divalent cations into self-containing,
dynamic protein depots at the microscale, which under physiological conditions leak …

Developing time‐sustained drug delivery systems is a main goal in innovative medicines.
Inspired by the architecture of secretory granules from the mammalian endocrine system it …

CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors
(GPCRs) superfamily and is specific for CXC chemokine ligand 12 (CXCL12, also known as …

Two human proteins involved in the inflammatory cell death, namely Gasdermin D (GSDMD)
and the Mixed Lineage Kinase Domain-Like (MLKL) protein have been engineered to …

The sustained release of small, tumor-targeted cytotoxic drugs is an unmet need in cancer
therapies, which usually rely on punctual administration regimens of non-targeted drugs …

Nanoscale protein materials show increasing applications in biotechnology and
biomedicine, addressing catalysis, drug delivery, or tissue engineering. Although protein …

Antibodies in oncology are being equipped with toxic cargoes and effector functions that can
kill cells at very low concentrations. A key challenge is that most targets on cancer cells are …

Biparatopic antibodies (bpAbs) bind distinct, non-overlapping epitopes on an antigen. This
unique binding mode enables new mechanisms of action beyond monospecific and …