Lifestyle factors conferring increased diabetes risk are associated with elevated basal
insulin levels (hyperinsulinaemia). The latter predicts later obesity in children and …

Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood
glucose levels. Excessive circulating insulin is associated with adipose tissue expansion …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be
recapitulated in the mouse, we compared C57BL/6J mice fed a Western‐style diet (WD) to …

Ipragliflozin is a novel and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor that
induces sustained increases in urinary glucose excretion by inhibiting renal glucose …

Ipragliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that increases
urinary glucose excretion by inhibiting renal glucose reabsorption and thereby causes a …

Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p‐
synephrine are widely used in weight loss and weight management as well as in sports …

Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in
neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by …

Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p‐synephrine are used
widely in weight loss/weight management and sports performance products. Because of …

The obesity epidemic has spawned an unlimited array of quick-fix, rapid weight loss plans
and unproven pharmaceuticals. Dangerous side effects and rebound weight gain has made …