The Role of Antioxidants in Ameliorating Cyclophosphamide‐Induced Cardiotoxicity

MA Ayza, KA Zewdie, BA Tesfaye… - Oxidative Medicine …, 2020 - Wiley Online Library
The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously
been shown to induce complications within the setting of bone marrow transplantation. More …

Resveratrol as a modulatory of apoptosis and autophagy in cancer therapy

R Yang, H Dong, S Jia, Z Yang - Clinical and Translational Oncology, 2022 - Springer
Cancer is one of the leading causes of death, with a heavy socio-economical burden for
countries. Despite the great advances that have been made in the treatment of cancer …

Neuroprotective effect of quercetin and nano-quercetin against cyclophosphamide-induced oxidative stress in the rat brain: role of Nrf2/HO-1/Keap-1 signaling …

DA AbdElrazek, MA Ibrahim, NH Hassan, EI Hassanen… - Neurotoxicology, 2023 - Elsevier
Quercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part
of the flavonoid family. Qu has a wide range of biological properties, such as …

Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury

HA Ebrahim, SS Kamar, MA Haidara, NSA Latif… - Naunyn-Schmiedeberg's …, 2022 - Springer
Chronic liver injury can lead to hepatic failure and the only available method of treatment
would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa …

Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model

T Yalcın, S Kaya, T Kuloğlu - Toxicology Mechanisms and Methods, 2024 - Taylor & Francis
One of the most important side effects of Doxorubicin (DOX), a chemotherapeutic agent, is
nephrotoxicity. The purpose of this study is to determine whether different doses of natural …

Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice

A Iqubal, S Sharma, MA Ansari, AK Najmi… - European Journal of …, 2019 - Elsevier
Incidence and prevalence of cancer is an alarming situation globally. For the treatment of
cancer many anticancer drugs have been developed but, unfortunately, their potential …

Myricetin abrogates cisplatin-induced oxidative stress, inflammatory response, and goblet cell disintegration in colon of wistar rats

MU Rehman, IA Rather - Plants, 2019 - mdpi.com
Cisplatin [cis-diamminedichloroplatinum II] is an extensively prescribed drug in cancer
chemotherapy; it is also useful for the treatment of diverse types of malignancies …

A novel protective role of sacubitril/valsartan in cyclophosphamide induced lung injury in rats: impact of miRNA-150-3p on NF-κB/MAPK signaling trajectories

GA Abdel-Latif, AHA Elwahab, RA Hasan… - Scientific reports, 2020 - nature.com
Cyclophosphamide (CP) is a chemotherapeutic agent that induces oxidative stress causing
multiple organ damage. Sacubitril/valsartan, is a combined formulation of neprilysin inhibitor …

Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation

X Zhou, Y Zhao, J Wang, X Wang, C Chen, D Yin… - Biochemical …, 2018 - Elsevier
Estrogen plays a pivotal role in the pathological development of breast cancer. Resveratrol
has chemo-preventive effects against breast cancer, whereas, the mechanism of antitumor …

Protection against cancer therapy-induced cardiovascular injury by planed-derived polyphenols and nanomaterials

Y Liao, Q Meng - Environmental Research, 2023 - Elsevier
Cancer therapy-induced heart injury is a significant concern for cancer patients undergoing
chemotherapy, radiotherapy, immunotherapy, and also targeted molecular therapy. The use …