The disease-modifying effects of hyaluronan in the osteoarthritic disease state

MA Nicholls, A Fierlinger, F Niazi… - … Insights: Arthritis and …, 2017 - journals.sagepub.com
Hyaluronic acid (HA) has been a treatment modality for patients with knee osteoarthritis (OA)
for many years now. Since HA was first introduced for the treatment of painful knee OA …

Non-invasive and in vivo assessment of osteoarthritic articular cartilage: a review on MRI investigations

AFM Hani, D Kumar, AS Malik, RMKR Ahmad… - Rheumatology …, 2015 - Springer
Early detection of knee osteoarthritis (OA) is of great interest to orthopaedic surgeons,
rheumatologists, radiologists, and researchers because it would allow physicians to provide …

Morphological and Quantitative Parametric MRI Follow-up of Cartilage Changes Before and After Intra-Articular Injection Therapy in Patients With Mild to Moderate …

M Tschopp, CWA Pfirrmann, F Brunner… - Investigative …, 2024 - journals.lww.com
Background Intra-articular injections are routinely used for conservative treatment of knee
osteoarthritis (OA). The detailed comparative therapeutic effects of these injections on …

In vivo high-resolution MRI (7T) of femoro-tibial cartilage changes in the rat anterior cruciate ligament transection model of osteoarthritis: a cross-sectional study

JC Goebel, R Bolbos, M Pham, L Galois… - …, 2010 - academic.oup.com
Objective. To assess OA-related changes in mean compartmental femorotibial cartilage
thickness in rat knees by three-dimensional (3D) MRI (7T). Methods. MRI was performed in …

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) shows no change in cartilage structural composition after viscosupplementation in patients with early …

J van Tiel, M Reijman, PK Bos, J Hermans… - PLoS …, 2013 - journals.plos.org
Introduction Viscosupplementation with hyaluronic acid (HA) of osteoarthritic (OA) knee
joints has a well-established positive effect on clinical symptoms. This effect, however, is …

The value of MR T2* measurements in normal and osteoarthritic knee cartilage: effects of age, sex, and location

PH Tsai, CC Wong, WP Chan, TW Lu - European Radiology, 2019 - Springer
Objectives Our aim was to investigate the role of age, sex, and location on MR T2* values of
the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). Methods A …

Sequential change in T2* values of cartilage, meniscus, and subchondral bone marrow in a rat model of knee osteoarthritis

PH Tsai, HS Lee, TY Siow, YC Chang, MC Chou… - PLoS …, 2013 - journals.plos.org
Background There is an emerging interest in using magnetic resonance imaging (MRI) T2*
measurement for the evaluation of degenerative cartilage in osteoarthritis (OA). However …

Effects of high molecular weight hyaluronic acid on induced arthritis of the temporomandibular joint in rats

GA Lemos, R Rissi, ER Pimentel, ET Palomari - Acta histochemica, 2015 - Elsevier
High molecular weight hyaluronic acid (HMWHA) has been used to treat temporomandibular
joint (TMJ) disorders, but controversial results have been described. This study aimed to …

In vitro and in vivo evaluation of doxycycline‐chondroitin sulfate/PCLmicrospheres for intraarticular treatment of osteoarthritis

O Aydin, F Korkusuz, P Korkusuz… - … Research Part B …, 2015 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease, which has no complete treatment with
medication yet. Intraarticular hyaluronan (HA) injection can decrease pain and modify the …

Ambivalent properties of hyaluronate and hylan during post-traumatic OA in the rat knee

L Galois, S Etienne, C Henrionnet… - Bio-Medical …, 2012 - content.iospress.com
Aim. To determine whether viscosupplementation with intra-articular (ia) low-or high-
molecular-weight hyaluronate (HA) injections influenced both chondral and synovial lesions …