Baculovirus is an insect virus which has been used for more than thirty years for production
of recombinant proteins in insect cells. However, baculovirus can also be harnessed for …

Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like
(TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic …

CRISPR technology is rapidly evolving, and the scope of CRISPR applications is constantly
expanding. CRISPR was originally employed for genome editing. Its application was then …

The epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide variety of tumor
types, including peritoneal carcinomatosis (PC) from gastrointestinal and gynecological …

Background Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is
attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the …

Baculovirus is an obligate parasitic virus of the phylum Arthropoda. Baculovirus including
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely used in …

In cystic fibrosis (CF), sustained infection and exuberant inflammation results in debilitating
and often fatal lung disease. Advancement in CF therapeutics has provided successful …

The advent of site-specific nucleases, particularly CRISPR/Cas9, provides researchers with
the unprecedented ability to manipulate genomic sequences. These nucleases are used to …

The invention provides an automated system for producing induced pluripotent stem cells
(iPSCs) from adult somatic cells. Further, the system is used for producing differentiated …

The interaction between CD40 ligand (CD40L) and CD40 can directly inhibit growth of
CD40-positive carcinoma cells and may indirectly inhibit tumor growth through coordination …