Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis

E Albuquerque‐Souza, SE Sahingur - Periodontology 2000, 2022 - Wiley Online Library
The liver carries out a wide range of functions ranging from the control of metabolites,
nutrient storage, and detoxification to immunosurveillance. While inflammation is essential …

Viruses, periodontitis, and comorbidities

F Teles, RG Collman, D Mominkhan… - Periodontology …, 2022 - Wiley Online Library
Seminal studies published in the 1990s and 2000s explored connections between
periodontal diseases and systemic conditions, revealing potential contributions of …

[PDF][PDF] Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

X Li, H Wang, X Yu, G Saha, L Kalafati, C Ioannidis… - Cell, 2022 - cell.com
Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune
responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid …

Illuminating the oral microbiome and its host interactions: animal models of disease

G Hajishengallis - FEMS Microbiology Reviews, 2023 - academic.oup.com
Periodontitis and caries are driven by complex interactions between the oral microbiome
and host factors, ie inflammation and dietary sugars, respectively. Animal models have been …

Novel insight into the mechanisms of the bidirectional relationship between diabetes and periodontitis

F Barutta, S Bellini, M Durazzo, G Gruden - Biomedicines, 2022 - mdpi.com
Periodontitis and diabetes are two major global health problems despite their prevalence
being significantly underreported and underestimated. Both epidemiological and …

[HTML][HTML] The roles of neutrophils linking periodontitis and atherosclerotic cardiovascular diseases

RA Irwandi, ST Chiesa, G Hajishengallis… - Frontiers in …, 2022 - frontiersin.org
Inflammation plays a crucial role in the onset and development of atherosclerosis.
Periodontitis is a common chronic disease linked to other chronic inflammatory diseases …

[HTML][HTML] Oral, tongue-coating microbiota, and metabolic disorders: a novel area of interactive research

Y Li, J Cui, Y Liu, K Chen, L Huang… - Frontiers in cardiovascular …, 2021 - frontiersin.org
Interactions between colonizing microbiota and the host have been fully confirmed, among
which the tongue-coating microbiota have a moderate rate of renewal and disease …

[HTML][HTML] Diabetes and oral health: summary of current scientific evidence for why transdisciplinary collaboration is needed

WS Borgnakke, P Poudel - Frontiers in Dental Medicine, 2021 - frontiersin.org
This Perspective provides a brief summary of the scientific evidence for the often two-way
links between hyperglycemia, including manifest diabetes mellitus (DM), and oral health. It …

Investigating oral and systemic pathways between unhealthy and healthy dietary patterns to periodontitis in adolescents: A population‐based study

SA Costa, GG Nascimento, PMG Colins… - Journal of Clinical …, 2022 - Wiley Online Library
Aim To investigate pathways between unhealthy and healthy dietary patterns and
periodontitis in adolescents (18–19 years of age). Materials and Methods This population …

Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities

I Mitroulis, G Hajishengallis… - Cardiovascular …, 2023 - academic.oup.com
Abstract Cardiometabolic disorders are chief causes of morbidity and mortality, with chronic
inflammation playing a crucial role in their pathogenesis. The release of differentiated …