Flow cytometry (FC) is a powerful technique for the rapid analysis of single cells in a mixture,
by means of light-scattering and fluorescence measurements. In biotechnology, the power of …

Industrial biotechnology encompasses a large area of multi-scale and multi-disciplinary
research activities. With the recent megatrend of digitalization sweeping across all …

With the continuous development, in the last decades, of analytical techniques providing
complex information at single cell level, the study of cell heterogeneity has been the focus of …

Multi-variable cell population balance models represent the most accurate and general way
of describing the complicated phenomena associated with cell growth, substrate …

A critical issue in the modeling of aerobic bioreactors is the close interaction between fluid
flow and the biological reactions. In particular, shear rate has a large effect on the broth …

Microbial cultures are comprised of heterogeneous cells that differ according to their size
and intracellular concentrations of DNA, proteins and other constituents. Recent advances …

Successful scale-up of bioprocesses requires that laboratory-scale performance is equally
achieved during large-scale production to meet economic constraints. In industry, heuristic …

Successful scale-up of biological fermentations requires the prevention of any performance
losses from lab to production scale. Modelling large-scale conditions, in particular, so-called …

Mammalian cell cultures represent the major source for a number of very high-value
biopharmaceutical products, including monoclonal antibodies (MAbs), viral vaccines, and …

Several Galerkin, Tau and Collocation (pseudospectral) approximations have been
developed for the solution of the multi-variable cell population balance model in its most …