Efficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues

F Limone, IG San Juan, JM Mitchell, JLM Smith… - Cell reports, 2023 - cell.com
Human pluripotent stem cells (hPSCs) are a powerful tool for disease modeling of hard-to-
access tissues (such as the brain). Current protocols either direct neuronal differentiation …

Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair …

DA Hart - International Journal of Molecular Sciences, 2023 - mdpi.com
Pluripotent neural stem or progenitor cells (NSC/NPC) have been reported in the brains of
adult preclinical models for decades, as have mesenchymal stem/stromal cells (MSC) been …

Differentiation and functional connectivity of fetal tectal transplants

AR Harvey - Neural Regeneration Research, 2023 - journals.lww.com
Data from studies analyzing the differentiation and functional connectivity of embryonic
neural tissue grafted into the mammalian nervous system has led to the clinical testing of the …

[HTML][HTML] More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease

LM Carr, S Mustafa, A Care… - Brain, Behavior, and …, 2024 - Elsevier
Age is the number one risk factor for developing a neurodegenerative disease (ND), such as
Alzheimer's disease (AD) or Parkinson's disease (PD). With our rapidly ageing world …

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS

F Limone, DA Mordes, A Couto, BJ Joseph, JM Mitchell… - Nature Aging, 2024 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a
progressive loss of motor function linked to degenerating extratelencephalic neurons/Betz …

[HTML][HTML] Epigenetic and transcriptional regulation of neuron phenotype

K Achim - The International Journal of Developmental Biology, 2024 - ijdb.ehu.eus
Understanding the structure and function of cells is central to cell biology and physiology.
The ability to control cell function may benefit biomedicine, such as cell-replacement therapy …

Development of adrenal 3-dimensional spheroid cultures: potential for the treatment of adrenal insufficiency and neurodegenerative diseases

C Steenblock, S Fliedner, GA Spinas… - … of Endocrine and …, 2024 - explorationpub.com
Aim: Regenerative and curative strategies would be desirable for neurodegenerative and
adrenal diseases, and multipotent adrenal stem cells are considered as promising biological …

Transcription Factor-Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells

YH Ng, JA Janas - Stem Cell-Based Neural Model Systems for Brain …, 2023 - Springer
The ability to differentiate pluripotent stem cells and to generate specific cell types is a long-
standing goal of regenerative medicine. This can be accomplished by recreating the …

A nagy (őssejt) kaland; pluripotens őssejtvonalak létrehozása, jellemzése és felhasználási lehetőségeik

Á Apáti - 2023 - real-d.mtak.hu
Kedves Olvasó! Ez egy rendhagyó dolgozat* 2. De rendhagyó az idő, amikor születik;
rendhagyó a téma, mert ez nemcsak tudományos értekezés, hanem beszámoló is életem …

[PDF][PDF] Confronting ALS: understanding multicellular contribution to neurodegeneration: computational anal sis and hiPSCs in itro modelling as a multidisciplinar …

F Limone - scholarlypublications …
Age–it's the one mountain you can't overcome, and as the average life expectancy extends
into the eighth decade, neurodegenerative diseases are becoming increasingly prevalent …