Nerve agents are organophosphorus chemical warfare agents that exert their action through
the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of …

There are two principal mechanisms of acetylcholine (ACh) release from the resting motor
nerve terminal: quantal and nonquantal (NQR); the former being only a small fraction of the …

G-protein coupled receptors are not considered to exhibit voltage sensitivity. Here, using
Xenopus oocytes, we show that the M 2 muscarinic receptor (m2R) is voltage-sensitive. The …

Terminal Schwann cells (TSCs) are key components of the mammalian neuromuscular
junction (NMJ). How the TSCs sense the synaptic activity in physiological conditions …

Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (α2–α10, β2–
β4), are expressed in autonomic ganglia, playing a central role in autonomic transmission …

For over three-quarters of a century, organophosphorus (OP) insecticides have been
ubiquitously used in agricultural, residential, and commercial settings and in public health …

After spinal cord transection (SCT) the interaction between motoneurons (MNs) and muscle
is impaired, due to reorganization of the spinal network after a loss of supraspinal inputs …

Publisher Summary An important function of all nervous systems is to control muscle
contraction so that movements of the body are appropriate to promote survival. In most …

Endocannabinoids (eCBs) inhibit neurotransmitter release throughout the central nervous
system. Using the Ceratomandibularis muscle from the lizard Anolis carolinensis we asked …

The effects of cholinergic drugs on the quantal contents of the nerve‐evoked endplate
currents (EPCs) and the parameters of the time course of quantal release (minimal synaptic …