Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …

Drugging the p53 pathway has been a goal for both academics and pharmaceutical
companies since the designation of p53 as the 'guardian of the genome'. Through growing …

The tumor suppressor protein p53 is mutated in close to 50% of human tumors and is
dysregulated in many others, for instance by silencing or loss of p14ARF. Under steady-state …

Stapled peptides are a promising class of molecules with potential as highly specific probes
of protein–protein interactions and as therapeutics. Hydrocarbon stapling affects the peptide …

Colon cancer is one of the most frequent malignant tumors, and microRNA (miR)‑205 is
involved in the tumor progression. The present study aimed to explore the effects of miR‑205 …

Misregulation and mutations of the transcription factor Nrf2 are involved in the development
of a variety of human diseases. In this study, we employed the technology of stapled …

Background: Antimicrobial Peptides (AMPs) are an attractive alternative to traditional small
molecule antibiotics as AMPs typically target the bacterial cell membrane. A Trp-rich peptide …

Grafting bioactive peptides into recipient protein scaffolds can often increase their activities
by conferring enhanced stability and cellular longevity. Here, we describe use of vGFP as a …

近年来, 蛋白多肽类药物因在治疗疾病方面具有显著的优点, 普遍受到研究者的青睐; 另一方面,
蛋白多肽类药物半衰期一般较短, 影响患者用药顺应性. 结合蛋白多肽类药物药动学特点 …