Roles of adipokines in digestive diseases: markers of inflammation, metabolic alteration and disease progression

ML Chang, Z Yang, SS Yang - International journal of molecular sciences, 2020 - mdpi.com
Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the
interorgan crosstalk network through adipokines, which cause pleiotropic effects, including …

The tumour immune microenvironment in oesophageal cancer

M Davern, NE Donlon, R Power, C Hayes… - British Journal of …, 2021 - nature.com
Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-
oesophageal reflux disease, obesity and tobacco use. Knowledge of the microenvironment …

The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies

J Lysaght, MJ Conroy - Nature Reviews Endocrinology, 2024 - nature.com
Epidemiology studies have demonstrated a clear association between obesity and the
development of several distinct malignancies, with excessive visceral adiposity being an …

Gold nanoparticles and obese adipose tissue microenvironment in cancer treatment

N Essa, F O'Connell, A Prina-Mello, J O'Sullivan… - Cancer Letters, 2022 - Elsevier
The epidemiological correlation between obesity and cancer is well characterized, but the
biological mechanisms which regulate tumor development and response to therapy in …

Help or hindrance: The obesity paradox in cancer treatment response

F O'Connell, J O'Sullivan - Cancer Letters, 2021 - Elsevier
Obesity is a rising epidemic, the influence of which on cancer development, progression as
well as its impact on current standard of care cancer treatments is profound with many …

Systematic review of NMR-based metabolomics practices in human disease research

K Huang, N Thomas, PR Gooley, CW Armstrong - Metabolites, 2022 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical
techniques for metabolomics. It has the advantages of minimal sample preparation and high …

Energy metabolism, metabolite, and inflammatory profiles in human ex vivo adipose tissue are influenced by obesity status, metabolic dysfunction, and treatment …

F O'Connell, E Mylod, NE Donlon, AB Heeran, C Butler… - Cancers, 2023 - mdpi.com
Simple Summary Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with
limited response rates to current treatment modalities and is strongly linked to obesity status …

Long-term variation in skeletal muscle and adiposity in patients undergoing esophagectomy

PR Boshier, F Klevebro, W Jenq… - Diseases of the …, 2021 - academic.oup.com
This study seeks to define long-term variation in body composition in patients undergoing
esophagectomy for cancer and to associate those changes with survival. Assessment of …

Translating Molecular Biology Discoveries to Develop Targeted Cancer Interception in Barrett's Esophagus

S Samaddar, D Buckles, S Saha, Q Zhang… - International journal of …, 2023 - mdpi.com
Esophageal adenocarcinoma (EAC) is a rapidly increasing lethal tumor. It commonly arises
from a metaplastic segment known as Barrett's esophagus (BE), which delineates the at-risk …

Fully automated 3D body composition analysis and its association with overall survival in head and neck squamous cell carcinoma patients

M Rozynek, D Gut, I Kucybała… - Frontiers in …, 2023 - frontiersin.org
Objectives We developed a method for a fully automated deep-learning segmentation of
tissues to investigate if 3D body composition measurements are significant for survival of …