Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …

Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

Abstract Homology-directed repair (HDR), a method for repair of DNA double-stranded
breaks can be leveraged for the precise introduction of mutations supplied by synthetic DNA …

Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for
maintaining genomic integrity. To systematically map these pathways, we developed a high …

Despite the potential of small molecules and recombinant proteins to enhance the efficiency
of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently …

DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …

Failure to complete DNA replication is one of the major sources of genome instability
leading to aneuploidy, chromosome breakage, and chromosome rearrangements that are …

DNA synthesis during homologous recombination is highly mutagenic and prone to template
switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene …

Cancer is one of the most widespread and severe diseases with a huge mortality rate. In
recent years, the second-leading mortality rate of any cancer globally has been breast …

Canonical CRISPR-Cas9 genome editing technique has profoundly impacted the fields of
plant biology, biotechnology, and crop improvement. Since non-homologous end joining …