Many tumors, including breast cancer, are maintained by a subpopulation of cells that
display stem cell properties, mediate metastasis, and contribute to treatment resistance …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Aneuploidy has been recognized as a common characteristic of cancer cells for> 100 years.
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …

Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) are
thought to be the direct consequence of mutational events induced by chemotherapy …

Hematopoiesis is a process capable of generating millions of cells every second, as
distributed in many cell types. The process is regulated by a number of transcription factors …

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in
mammals. Although this family was originally identified in the context of the type I interferon …

Contemporary treatment of pediatric acute myeloid leukemia (AML) requires the assignment
of patients to specific risk groups. To explore whether expression profiling of leukemic blasts …

Breast cancer is the leading cause of cancer death among women worldwide. Accumulating
evidence indicates that the local recurrent and/or distant metastatic tumors, the major causes …

The use of combination chemotherapy to cure acute lymphoblastic leukaemia (ALL) in
children emerged in the 1980s as a paradigm for curing any disseminated cancer, and many …

Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …