Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA
polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of …

Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

Eviction or destabilization of nucleosomes from chromatin is a hallmark of functional
regulatory elements in eukaryotic genomes. Historically identified by nuclease …

Transcriptional enhancers are the primary determinants of tissue-specific gene expression.
Although the majority of our current knowledge of enhancer elements comes from detailed …

The molecular mechanisms through which alternative splicing and histone modifications
regulate gene expression are now understood in considerable detail. Here, we discuss …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Histone modifications and RNA splicing, two seemingly unrelated gene regulatory
processes, greatly increase proteome diversity and profoundly influence normal as well as …

The transition between initiation and productive elongation during RNA Polymerase II (Pol II)
transcription is a well-appreciated point of regulation across many eukaryotes. Elongating …

Alternative RNA splicing is a key step in gene expression that allows generation of
numerous messenger RNA transcripts encoding proteins of varied functions from the same …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale international …