Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

K O'Brien, S Ughetto, S Mahjoum, AV Nair… - Cell reports, 2022 - cell.com
Extracellular vesicles (EVs) are membrane-encapsulated particles that carry genetically
active and protein/lipid cargo that can affect the function of the recipient cell. A number of …

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

D Yuan, Y Zhao, WA Banks, KM Bullock, M Haney… - Biomaterials, 2017 - Elsevier
Recent work has stimulated interest in the use of exosomes as nanocarriers for delivery of
small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the …

Exosomes as drug delivery vehicles for Parkinson's disease therapy

MJ Haney, NL Klyachko, Y Zhao, R Gupta… - Journal of controlled …, 2015 - Elsevier
Exosomes are naturally occurring nanosized vesicles that have attracted considerable
attention as drug delivery vehicles in the past few years. Exosomes are comprised of natural …

Using exosomes, naturally-equipped nanocarriers, for drug delivery

EV Batrakova, MS Kim - Journal of Controlled Release, 2015 - Elsevier
Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …

[HTML][HTML] Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

N Yim, SW Ryu, K Choi, KR Lee, S Lee, H Choi… - Nature …, 2016 - nature.com
Nanoparticle-mediated delivery of functional macromolecules is a promising method for
treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have …

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

D Rufino-Ramos, PR Albuquerque, V Carmona… - Journal of Controlled …, 2017 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all
cells, including brain cells. EVs are a major term that includes apoptotic bodies …

Cell-based drug delivery systems and their in vivo fate

L Yang, Y Yang, Y Chen, Y Xu, J Peng - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cell-based drug delivery systems (DDSs) have received attention recently because of their
unique biological properties and self-powered functions, such as excellent biocompatibility …

Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain

J Nong, PM Glassman, JW Myerson… - ACS …, 2023 - ACS Publications
Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …