Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

An update on dual targeting strategy for cancer treatment

YD Taghipour, A Zarebkohan, R Salehi… - Journal of Controlled …, 2022 - Elsevier
The key issue in the treatment of solid tumors is the lack of efficient strategies for the targeted
delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) …

Nanoparticle shape determines dynamics of targeting nanoconstructs on cell membranes

P Choo, T Liu, TW Odom - Journal of the American Chemical …, 2021 - ACS Publications
Nanoparticle carriers are effective drug delivery vehicles. Along with other design
parameters including size, composition, and surface charge, particle shape strongly …

Ligand Separation on Nanoconstructs Affects Targeting Selectivity to Protein Dimers on Cell Membranes

YL Wu, K Lee, B Diloknawarit, TW Odom - Nano letters, 2023 - ACS Publications
This work demonstrates that targeting ligand density on nanoparticles can affect interactions
between the nanoconstructs and cell membrane receptors. We discovered that when the …

Deep Tumor Penetrating Gold Nano‐Adjuvant for NIR‐II‐Triggered In Situ Tumor Vaccination

A Chen, L Wu, Y Luo, S Lu, Y Wang, Z Zhou, D Zhou… - Small, 2022 - Wiley Online Library
Local tumor photothermal treatment with the near‐infrared light at the second window (NIR‐
II) is a promising strategy in triggering the in situ tumor vaccination (ISTV) for cancer therapy …

Nanoparticle Anisotropy Increases Targeting Interactions on Live-Cell Membranes

B Diloknawarit, K Lee, P Choo, TW Odom - ACS nano, 2024 - ACS Publications
This paper describes how branch lengths of anisotropic nanoparticles can affect interactions
between grafted ligands and cell-membrane receptors. Using live-cell, single-particle …

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

RP Friedrich, M Kappes, I Cicha, R Tietze… - International journal …, 2022 - Taylor & Francis
Label-free detection of nanoparticles is essential for a thorough evaluation of their cellular
effects. In particular, nanoparticles intended for medical applications must be carefully …

Single-nanoparticle orientation sensing by deep learning

J Hu, T Liu, P Choo, S Wang, T Reese… - ACS central …, 2020 - ACS Publications
This paper describes a computational imaging platform to determine the orientation of
anisotropic optical probes under differential interference contrast (DIC) microscopy. We …

In situ decrypting plasmonic nanoparticle size-controlled phosphorylation of epidermal growth factor receptor in living cells

H Wang, Y Ding, Y Zhang, X Shi, H Liu - Chemical Communications, 2023 - pubs.rsc.org
Recently, interaction between epidermal growth factor receptor (EGFR) and EGFR-targeted
nanoprobes is a hot topic. Here, we use dark field microscope (DFM) observe different …

Retracted Article: Single gold nanostars with multiple branches as multispectral orientation probes in single-particle rotational tracking

GW Kim, JW Ha - Chemical Communications, 2021 - pubs.rsc.org
Herein, we performed a single-particle correlation study to characterize the optical
properties of gold nanostars (AuNSs) with multiple sharp branches under dark-field (DF) and …