The epitranscriptome encompasses all post-transcriptional modifications that occur on
RNAs. These modifications can alter the function and regulation of their RNA targets, which …

Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory,
ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an …

Efficient manufacture of recombinant adeno-associated virus (rAAV) vectors for gene
therapy remains challenging. Packaging cell lines containing stable integration of the AAV …

MicroRNAs (miRNAs) are approximately 22 nucleotide (nt) long and play important roles in
post-transcriptional regulation in both plants and animals. In animals, precursor (pre-) …

Human adenoviruses (HAdVs) are common pathogens associated with a wide variety of
respiratory, ocular, and gastrointestinal diseases. To achieve its effective lytic mode of …

Human adenoviruses (HAdV) express either one or two virus-associated RNAs (VA RNAI or
VA RNAII). The structure of VA RNA resembles human precursor microRNAs (pre-miRNA) …

Abstract Primary Sclerosing Cholangitis (PSC) is closely associated with immune disorders
influenced by both genetic and environmental factors. The role of post-translational …

Adeno-associated virus (AAV) shows great promise for gene therapy, however scalability,
yield and quality remain significant issues. The most common 'helper-free'method used to …

In 2017, a novel miRNA was found at the MLTU-region of adenoviral genome, termed as
MLP-TSS-sRNA. This current study started with performing a series of mutations in the MLP …

An RNA molecule (1) comprises a RNA fragment (2) and a hairpin RNA fragment (3). The
hairpin RNA fragment (3) comprises a first stem region (10) comprising the RNA sequence …