Macrophages play an important role in cancer development and metastasis.
Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 …

CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer
cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the …

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …

Tissue-resident macrophages (TRMs) are heterogeneous populations originating either
from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid …

Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Inhibitory immune checkpoint blockade has been one of the most significant advances in
anticancer therapy of the past decade. Research so far has largely focused on improving …

Necroptosis contributes to hepatocyte death in nonalcoholic steatohepatitis (NASH), but the
fate and roles of necroptotic hepatocytes (necHCs) in NASH remain unknown. We show …

The success of cancer immunotherapy has generated tremendous interest in identifying new
immunotherapeutic targets. To date, the majority of therapies have focussed on stimulating …

The adaptive immune checkpoints such as PD-1 (programmed death-1)/PD-L1
(programmed death-ligand 1) play an important role in cancer immunotherapy, whereas …

Oncology has recently undergone a revolutionary change with widespread adoption of
immunotherapy for many cancers. Immunotherapy using monoclonal antibodies against …