Understanding bacteriophage tail fiber interaction with host surface receptor: the key “blueprint” for reprogramming phage host range

J Taslem Mourosi, A Awe, W Guo, H Batra… - International Journal of …, 2022 - mdpi.com
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …

Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Engineered reporter phages for detection of Escherichia coli, Enterococcus, and Klebsiella in urine

S Meile, J Du, S Staubli, S Grossmann… - Nature …, 2023 - nature.com
The rapid detection and species-level differentiation of bacterial pathogens facilitates
antibiotic stewardship and improves disease management. Here, we develop a rapid …

CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance

A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

[HTML][HTML] A perfect fit: Bacteriophage receptor-binding proteins for diagnostic and therapeutic applications

J Klumpp, M Dunne, MJ Loessner - Current opinion in microbiology, 2023 - Elsevier
Bacteriophages are the most abundant biological entity on earth, acting as the predators
and evolutionary drivers of bacteria. Owing to their inherent ability to specifically infect and …

Drivers and consequences of bacteriophage host range

D Holtappels, P Alfenas-Zerbini… - FEMS Microbiology …, 2023 - academic.oup.com
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …

Genetic engineering of bacteriophages: Key concepts, strategies, and applications

W Hussain, X Yang, M Ullah, H Wang, A Aziz… - Biotechnology …, 2023 - Elsevier
Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …

[HTML][HTML] Engineering therapeutic phages for enhanced antibacterial efficacy

S Meile, J Du, M Dunne, S Kilcher… - Current opinion in virology, 2022 - Elsevier
The alarming rise in antimicrobial resistance coupled with a lack of innovation in antibiotics
has renewed interest in the development of alternative therapies to combat bacterial …

Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers

R Ayala, AV Moiseenko, TH Chen, EE Kulikov… - Nature …, 2023 - nature.com
The T5 family of viruses are tailed bacteriophages characterized by a long non-contractile
tail. The bacteriophage DT57C is closely related to the paradigmal T5 phage, though it …

Flagellotropic bacteriophages: opportunities and challenges for antimicrobial applications

NC Esteves, BE Scharf - International Journal of Molecular Sciences, 2022 - mdpi.com
Bacteriophages (phages) are the most abundant biological entities in the biosphere. As
viruses that solely infect bacteria, phages have myriad healthcare and agricultural …