Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian
cancers. Mechanistic insight into the functions of human BRCA2 has been limited by the …

Repair of DNA interstrand crosslinks requires action of multiple DNA repair pathways,
including homologous recombination. Here, we report a de novo heterozygous T131P …

Proper repair of DNA double strand breaks (DSBs) is vital for the preservation of genomic
integrity. There are two main pathways that repair DSBs, Homologous recombination (HR) …