[HTML][HTML] Synthetic CpG-ODN rapidly enriches immune compartments in neonatal chicks to induce protective immunity against bacterial infections

T Gunawardana, KA Ahmed, K Goonewardene… - Scientific Reports, 2019 - nature.com
Abstract Oligodeoxynucleotides containing CpG motifs (CpG-ODN) induce innate immunity
against bacterial infections. Despite recent advances, how CpG-ODN alone protects against …

Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B …

L Die, P Yan, ZJ Jiang, TM Hua, W Cai, L Xing - Molecular immunology, 2012 - Elsevier
Bone-forming osteoblasts have been recently reported capable of expressing the critical co-
stimulatory molecule CD40 upon exposure to bacterial infection, which supports the …

[HTML][HTML] Mucosal delivery of CpG-ODN mimicking bacterial DNA via the intrapulmonary route induces systemic antimicrobial immune responses in neonatal chicks

K Goonewardene, KA Ahmed, T Gunawardana… - Scientific Reports, 2020 - nature.com
The transition to antibiotic-free poultry production in the face of pathogenic threats is a very
challenging task. We recently demonstrated that mucosal delivery of CpG-ODN alone by the …

[HTML][HTML] Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease

SV Chemmannur, AJ Badhwar, B Mirlekar… - Mucosal …, 2015 - Elsevier
Asthma is a complex airway allergic disease involving the interplay of various cell types,
cytokines, and transcriptional factors. Though many factors contribute to disease etiology …

Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway

F Junyent, L de Lemos, E Verdaguer… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 117, 244–252. Abstract JNK3 is mainly expressed in the CNS and it
plays a crucial role in neuronal death in several neurodegenerative diseases. By contrast …

Neuroprotective effect of AG490 in experimental traumatic brain injury of rats

A DU, T Ji, Y Bin, J Cao, X Zhang, LI Yu… - Chinese Medical …, 2013 - journals.lww.com
Background Traumatic brain injury (TBI) is a major cause of death and disability in children
and young adults worldwide. Therefore, we investigated the role of AG490 in regulating …

[PDF][PDF] INTRAPULMONARY DELIVERY OF OLIGODEOXYNUCLEOTIDES CONTAINING CYTOSINE PHOSPHODIESTER GUANINE MOTIFS (CPG-ODN) TO …

KVB Goonewardene - 2019 - harvest.usask.ca
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) are known for their ability to
stimulate the vertebral immune system and provide protection against pathogens. We have …

[PDF][PDF] IMMUNOPROTECTIVE MECHANISMS ASSOCIATED WITH IN OVO DELIVERY OF OLIGODEOXYNUCLEOTIDES CONTAINING CpG MOTIFS (CpG-ODN) …

TA Gunawardana - 2018 - harvest.usask.ca
Oligodeoxynucleotides containing CpG motifs (CpG-ODNs) are known for their ability to
stimulate vertebral immune system and provide protection against pathogens. Although CpG …

[图书][B] Hematopoietic cell lineage switching mediated by zebrafish STAT1B

H Song - 2010 - search.proquest.com
A critical question for developmental biology is the mechanism by which cells make fate
decisions. In the hematopoietic system, stern cells differentiate into several different cell …

[引用][C] AG490 对大鼠脑损伤后脑水肿及炎症反应的影响

曹健锋, 杜爱玲, 曾现伟, 杨斌, 王佰胜, 季泰令 - 潍坊医学院学报, 2012