The biology of regeneration failure and success after spinal cord injury

AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Current options for cell therapy in spinal cord injury

I Vismara, S Papa, F Rossi, G Forloni… - Trends in molecular …, 2017 - cell.com
Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical
injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes …

[HTML][HTML] Origin of new glial cells in intact and injured adult spinal cord

F Barnabé-Heider, C Göritz, H Sabelström… - Cell stem cell, 2010 - cell.com
Several distinct cell types in the adult central nervous system have been suggested to act as
stem or progenitor cells generating new cells under physiological or pathological conditions …

Ependymal cells: biology and pathology

MR Del Bigio - Acta neuropathologica, 2010 - Springer
The literature was reviewed to summarize the current understanding of the role of ciliated
ependymal cells in the mammalian brain. Previous reviews were summarized. Publications …

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

A Shao, S Tu, J Lu, J Zhang - Stem cell research & therapy, 2019 - Springer
The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not
effective. Stem cells are a type of cells that have the potential to differentiate into various …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel

AJ Mothe, RY Tam, T Zahir, CH Tator, MS Shoichet - Biomaterials, 2013 - Elsevier
Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration,
and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a …

Advances in stem cell therapy for spinal cord injury

AJ Mothe, CH Tator - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …

Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction

ZS Ji, GB Gao, YM Ma, JX Luo, GW Zhang, H Yang… - Biomaterials, 2022 - Elsevier
Generation of a promising antioxidative reagent with superior biocompatibility is urgently
needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the …

Stem cells therapy for spinal cord injury

M Gazdic, V Volarevic, CR Harrell… - International journal of …, 2018 - mdpi.com
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously
healthy young adults. Current therapeutic strategies for SCI includes surgical …