One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of
the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant …

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by abnormally low
cellular levels of the ubiquitous protein SMN. Traditionally, reduced levels of SMN were …

Spinal muscular atrophy (SMA) is a devastating motor neuron disease that predominantly
affects children and represents the most common cause of hereditary infant mortality. The …

Spinal muscular atrophy (SMA) is a motor neuron disease caused by deficiency of the
ubiquitous survival motor neuron (SMN) protein. To define the mechanisms of selective …

Spinal muscular atrophy (SMA) is an autosomal-recessive disorder characterized by α-motor
neuron loss in the spinal cord anterior horn. SMA results from deletion or mutation of the …

Spinal muscular atrophies (SMAs) are a group of inherited disorders characterized by motor
neuron loss in the spinal cord and lower brainstem, muscle weakness, and atrophy. The …

At the post-transcriptional level, expression of protein-coding genes is controlled by a series
of RNA regulatory events including nuclear processing of primary transcripts, transport of …

Spinal muscular atrophy (SMA), a motoneuron disease caused by a deficiency of the
survival of motor neuron (SMN) protein, is characterized by motoneuron loss and muscle …

Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in
gene regulation. However, the role of the basal splicing machinery in regulating AS remains …