Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …

Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported
to repress cancer growth and improve therapeutic responses in several preclinical settings …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing
biomolecules that control multiple essential cellular activities. Altered cysteine metabolism …

Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

Abstract Acylphosphatase 1 (ACYP1), a protein located in the mammalian cell cytoplasm,
has been shown to be associated with tumor initiation and progression by functioning as a …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

One-carbon metabolism is an essential branch of cellular metabolism that intersects with
epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit …