[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
[HTML][HTML] Studying human neurological disorders using induced pluripotent stem cells: from 2D monolayer to 3D organoid and blood brain barrier models
S Logan, T Arzua, SG Canfield… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …
due to their severe consequences on quality of life and prevalence throughout the world …
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …
modeling neurological diseases. However, iPSC models are fraught with technical …
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls
The ability to precisely edit the genome of human induced pluripotent stem cell (iPSC) lines
using CRISPR/Cas9 has enabled the development of cellular models that can address …
using CRISPR/Cas9 has enabled the development of cellular models that can address …
Electrophysiological analysis of brain organoids: current approaches and advancements
AP Passaro, SL Stice - Frontiers in Neuroscience, 2021 - frontiersin.org
Brain organoids, or cerebral organoids, have become widely used to study the human brain
in vitro. As pluripotent stem cell-derived structures capable of self-organization and …
in vitro. As pluripotent stem cell-derived structures capable of self-organization and …
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons
Membrane potential is a key aspect of cellular signalling and is dynamically regulated by an
array of ion-selective pumps and channels. Fluorescent voltage indicators enable non …
array of ion-selective pumps and channels. Fluorescent voltage indicators enable non …
Pooled genetic screens with image‐based profiling
Spatial structure in biology, spanning molecular, organellular, cellular, tissue, and
organismal scales, is encoded through a combination of genetic and epigenetic factors in …
organismal scales, is encoded through a combination of genetic and epigenetic factors in …
Advances in the automation of whole-cell patch clamp technology
Electrophysiology is the study of neural activity in the form of local field potentials, current
flow through ion channels, calcium spikes, back propagating action potentials and somatic …
flow through ion channels, calcium spikes, back propagating action potentials and somatic …
Genome editing in iPSC-based neural systems: from disease models to future therapeutic strategies
A McTague, G Rossignoli, A Ferrini, S Barral… - Frontiers in Genome …, 2021 - frontiersin.org
Therapeutic advances for neurological disorders are challenging due to limited accessibility
of the human central nervous system and incomplete understanding of disease …
of the human central nervous system and incomplete understanding of disease …
'Channeling'therapeutic discovery for epileptic encephalopathy through iPSC technologies
D Simkin, C Ambrosi, KA Marshall, LA Williams… - Trends in …, 2022 - cell.com
Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the
field of in vitro disease modeling, granting us access to disease-pertinent human cells of the …
field of in vitro disease modeling, granting us access to disease-pertinent human cells of the …