It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and
cholesterol metabolism. However, over the last decades, a variety of pathological conditions …

Peroxisome proliferator‐activated receptor gamma (PPARγ) is a vital subtype of the PPAR
family. The biological functions are complex and diverse. PPARγ plays a significant role in …

Hesperidin is a plant-derived bioflavonoid with promising antitumor efficacy, though the
underlying mechanisms of action remain poorly elucidated. Thus, we evaluated the in vivo …

Hepatocellular carcinoma (HCC) is a significant health problem worldwide with poor
prognosis. Drug repositioning represents a profitable strategy to accelerate drug discovery …

Liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and
lipoproteins. Hepatocellular carcinoma (HCC) is one of the most common fatal malignant …

Background Accumulating evidence confirm that aberrant microRNAs (miRNAs) expression
contributes to hepatocellular carcinoma (HCC) development and progression. Previous …

Abstract Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC).
However, the direct causative effect of COX-2 in spontaneous HCC formation remains …

Background: We have previously demonstrated that peroxisome proliferator-activated
receptor (PPARγ) activation inhibits hepatocarcinogenesis. We aim to investigate the effect …

Thiazolidinediones are a class of Peroxisome Proliferator Activated Receptor γ (PPARγ)
agonists that reduce insulin resistance in type 2 diabetic patients. Although no detectable …

Higher eukaryotic development is a complex and tightly regulated process, whereby
transcription factors (TFs) play a key role in controlling the gene regulatory networks …