Highlights of the latest developments in radiopharmaceuticals for infection imaging and future perspectives

E Dadachova, DEN Rangel - Frontiers in Medicine, 2022 - frontiersin.org
COVID-19 pandemic has heightened the interest toward diagnosis and treatment of
infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission …

99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

SAR Naqvi - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Discovery of penicillin marked a turning point in the history of infection therapy which also
led to the emergence of bacterial resistance. It is now 100 years to fight with ever‐muted …

99mTc-radiolabeled Levofloxacin and micelles as infection and inflammation imaging agents

M Silindir-Gunay, AY Ozer - Journal of drug delivery science and …, 2020 - Elsevier
Easy and early detection of infection and inflammation is essential for early and effective
treatment. In this study, PEGylated micelles were designed and both micelles and …

New imaging tracers for the infected diabetic foot (nuclear and optical imaging)

AO Ankrah, HC Klein, PH Elsinga - Current Pharmaceutical …, 2018 - ingentaconnect.com
Diabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden
on patients, their families and healthcare systems and increased mortality. Early diagnosis …

Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inflammation and infection

T Kniess, M Laube, F Wüst, J Pietzsch - Dalton transactions, 2017 - pubs.rsc.org
In nuclear medicine, the detection of inflamed and infected lesions is of growing interest.
Extensive efforts have been made to develop radiopharmaceuticals specific for inflammation …

[HTML][HTML] Radiosynthesis and Preclinical Evaluation of [99mTc]Tc-Tigecycline Radiopharmaceutical to Diagnose Bacterial Infections

SM Saleem, T Jabbar, MB Imran, A Noureen… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: As a primary source of mortality and disability, bacterial infections
continue to develop a severe threat to humanity. Nuclear medicine imaging (NMI) is known …

Radiolabeling, characterization, and preclinical evaluation of plazomicin: A potential tracer for bacterial infection

OA El‐kawy, G Abdelaziz… - Chemical Biology & …, 2022 - Wiley Online Library
In this study, 99mTc–plazomicin, a new radio‐antibiotic complex, was prepared specifically
for bacterial infection localization and monitoring. Factors affecting the labeling reaction …

Recent Advancements in Radiopharmaceuticals for Infection Imaging

E Dadachova, DEN Rangel - Intracellular Pathogens: Methods and …, 2024 - Springer
COVID-19 pandemic has heightened the interest toward diagnosis and treatment of
infectious diseases. Nuclear medicine, with its powerful scintigraphic, single photon …

Susceptibility of 99mTc-Ciprofloxacin for Common Infection Causing Bacterial Strains Isolated from Clinical Samples: an In Vitro and In Vivo Study

SAR Naqvi, S Roohi, H Sabir, SA Shahzad… - Applied biochemistry …, 2019 - Springer
Abstract 99m Tc-ciprofloxacin scintigraphy is useful in the detection of gram-positive and
gram-negative bacterial infections and also for differentiating the infection from aseptic …

Technetium‐99m radiolabeling and biological study of epirubicin for in vivo imaging of multi‐drug‐resistant Staphylococcus aureus infections via single photon …

NUH Khan, SAR Naqvi, S Roohi… - Chemical Biology & …, 2019 - Wiley Online Library
The development of functional imaging is a promising strategy for diagnosis and treatment of
infectious and cancerous diseases. In this study, epirubicin was developed as a [99mTc] …