Heterogeneity is a hallmark of the adaptive immune system. This is most evident in the
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …

A large set of peptide antigens presented by class I major histocompatibility complex (MHC)
molecules on human and murine melanomas and recognized by CD8+ T cells have been …

CD4+ T cells are known to provide support for the activation and expansion of primary CD8+
T cells, their subsequent differentiation, and ultimately their survival as memory cells …

We have established that the route of immunization with peptide-pulsed, activated DC leads
to memory CD8+ T cells with distinct distributions in lymphoid tissues, which determines the …

Posttranslational modification of peptide antigens has been shown to alter the ability of T
cells to recognize major histocompatibility complex (MHC) class I–restricted peptides …

The expansion of CD8+ T cells in response to Ag can be characterized as either dependent
or independent of CD4+ T cells. The factors that influence this dichotomy are poorly …

The human tyrosinase-derived peptide Y MDGTMSQV is presented on the surface of human
histocompatibility leukocyte antigen (HLA)-A* 0201+ melanomas and has been suggested …

Recently, human dendritic cells (DCs) pulsed with mRNA encoding a broad range of tumor
antigens have proven to be potent activators of a primary anti–tumor-specific T-cell response …

Human minor histocompatibility Ags (mHag) present significant barriers to successful bone
marrow transplantation. However, the structure of human mHag and the basis for antigenic …

Antitumor vaccines encoding self-antigens generally have low immunogenicity in clinical
trials. Several approaches are aimed at improving vaccine immunogenicity, including efforts …