Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Oral carcinoma represents one of the main carcinomas of the head and neck region, with a 5-
year survival rate of less than 50%. Smoking and tobacco use are recognized risk factors …

Lung cancer remains one of the most common malignancies in the world. Nowadays, the
most common lung cancer is non-small cell lung cancer (NSCLC), namely …

Aortic dissection (AD) has an unfavorable prognosis. It requires early diagnosis, appropriate
treatment strategies, and suspicion to recognize symptoms; thus, it is commonly described …

Simple Summary Head and neck squamous cell carcinoma (HNSCC) is the neoplasm with
the highest incidence in the head and neck regions. More than 350,000 new cases of …

Alterations in histone modification have been linked to cancer development and
progression. Celastrol, a Chinese herbal compound, shows potent anti-tumor effects through …

Abstract p300/CBP histone acetyltransferases (HAT) are critical transcription coactivators
involved in multiple cellular activities. They act at multiple levels in non-small cell lung …

Small molecule kinase inhibitors are one of the fastest growing classes of drugs, which are
approved by the US Food and Drug Administration (FDA) for cancer and noncancer …

Epigenetic modification is a complex process of reversible and heritable alterations in gene
function, and the combination of epigenetic and metabolic alterations is recognized as an …

Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD‑
1)/programmed death ligand 1 (PD‑L1) axis have achieved marked and durable efficacy in …