Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

The complex network of neuronal cells in the retina makes it a potential target of neuronal
toxicity–a risk factor for visual loss. With growing use of nanoparticles (NPs) in commercial …

Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal
ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their …

The basic helix–loop–helix (bHLH) transcription factor Math5 (Atoh7) is transiently
expressed during early retinal histogenesis and is necessary for retinal ganglion cell (RGC) …

purpose. To develop and characterize a retinal explant culture system to facilitate
investigation of novel methods of improving retinal stem cell therapy. methods. Retinas …

Background Mitochondrial dysfunction has been implicated in the pathologies of a number
of retinal degenerative diseases in both the outer and inner retina. In the outer retina …

Age-related Macular Degeneration (AMD) is an up-to-date untreatable chronic
neurodegenerative eye disease of multifactorial origin, and the main causes of blindness in …

Math5, a mouse homolog of the Drosophila proneural bHLH transcription factor Atonal, is
essential in the developing retina to establish retinal progenitor cell competence for a …

The vertebrate basic helix–loop–helix (bHLH) transcription factor ATOH7 (Math5) is
specifically expressed in the embryonic neural retina and is required for the genesis of …

Purpose: The purpose of this study was characterization of adult murine neuroretina in
organ culture to investigate its suitability for use in preclinical therapeutic applications. In …