Consideration of pathways for immunotoxicity of per-and polyfluoroalkyl substances (PFAS)

V Ehrlich, W Bil, R Vandebriel, B Granum, M Luijten… - Environmental …, 2023 - Springer
Background Per-and polyfluoroalkyl substances (PFAS) are of public health concern,
because of their ubiquitous and extremely persistent occurrence, and depending on their …

[HTML][HTML] Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies

Z Zeng, B Song, R Xiao, G Zeng, J Gong, M Chen… - Environment …, 2019 - Elsevier
The wide use of perfluorooctane sulfonate (PFOS) has led to increasing concern about its
human health risks over the past decade. In vivo and in vitro studies are important and …

Risk to human health related to the presence of perfluoroalkyl substances in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …

Neurotransmission targets of per-and polyfluoroalkyl substance neurotoxicity: mechanisms and potential implications for adverse neurological outcomes

JM Brown-Leung, JR Cannon - Chemical research in toxicology, 2022 - ACS Publications
Per-and polyfluoroalkyl substances (PFAS) are a group of persistent environmental
pollutants that are ubiquitously found in the environment and virtually in all living organisms …

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro

AM Tukker, LMS Bouwman, RGDM van Kleef… - Scientific reports, 2020 - nature.com
Concerns about the neurotoxic potential of polyfluoroalkyl substances (PFAS) such as
perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) increase, although …

[HTML][HTML] Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells …

N Davidsen, AJ Lauvås, O Myhre, E Ropstad… - Reproductive …, 2021 - Elsevier
Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances
(PFASs), brominated flame retardants (BFRs), organochlorine pesticides and …

Association between prenatal exposure to per-and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort

X Gao, Q Zuo, X Fu, L Song, M Cen, J Wu - Environmental Research, 2023 - Elsevier
Background Although numerous studies have examined the effect of prenatal per-and
polyfluoroalkyl substances (PFAS) exposure on neurodevelopment in children, findings …

PFOA evokes extracellular Ca2+ influx and compromises progesterone-induced response in human sperm

Y Yuan, X Ding, Y Cheng, H Kang, T Luo, X Zhang… - Chemosphere, 2020 - Elsevier
Perfluorooctane acid (PFOA), a persistent organic pollutant, is ubiquitously present in the
environment and may detrimentally affect male reproductive health. In this study, mature …

Nrf2 signaling elicits a neuroprotective role against PFOS-mediated oxidative damage and apoptosis

P Sun, X Nie, X Chen, L Yin, J Luo, L Sun, C Wan… - Neurochemical …, 2018 - Springer
Perfluorooctanesulfonate (PFOS) may cause neurotoxicity through the initiation of oxidative
stress. In the current study, we investigated the role of anti-oxidant nuclear factor erythroid 2 …

Structure-based virtual screening of perfluoroalkyl and polyfluoroalkyl substances (PFASs) as endocrine disruptors of androgen receptor activity using molecular …

ERA Singam, P Tachachartvanich, D Fourches… - Environmental …, 2020 - Elsevier
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) pose a substantial threat as
endocrine disruptors, and thus early identification of those that may interact with steroid …