Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the
Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory …

There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …

There is a brief summary of the background literature about purinergic signalling. The review
then considers purinergic mechanosensory transduction involved in visceral, cutaneous and …

Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-
regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such …

Seven mammalian purinergic receptor subunits, denoted P2X1–P2X7, and several spliced
forms of these subunits have been cloned. When heterologously expressed, these cDNAs …

Increasing evidence indicates the importance of extracellular adenosine triphosphate (ATP)
in the modulation of neuronal function. In particular, fine control of ATP release and the …

ATP-gated P2X3 receptors are mostly expressed by nociceptive sensory neurons and
participate in transduction of pain signals. P2X3 receptors show a combination of fast …

Pain represents a very large social and clinical problem since the current treatment provides
insufficient pain relief. Plasticity of pain receptors together with sensitisation of sensory …

Background: The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of
voltage-gated P/Q Ca2+ channels (Cav2. 1), is associated with familial hemiplegic migraine …