The interplay of signaling pathways and miRNAs in the pathogenesis and targeted therapy of esophageal cancer

AS Doghish, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the
second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as …

A step-by-step microRNA guide to cancer development and metastasis

GS Markopoulos, E Roupakia, M Tokamani… - Cellular Oncology, 2017 - Springer
Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures

SV Vasaikar, AP Deshmukh, P den Hollander… - British journal of …, 2021 - nature.com
Background The epithelial-mesenchymal transition (EMT) enables dissociation of tumour
cells from the primary tumour mass, invasion through the extracellular matrix, intravasation …

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150 …

W Lu, H Zhang, Y Niu, Y Wu, W Sun, H Li, J Kong… - Molecular cancer, 2017 - Springer
Background The function of a new long non-coding RNA linc00673 remains unclear. While
identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was …

Liquid biopsy: miRNA as a potential biomarker in oral cancer

S Mazumder, S Datta, JG Ray, K Chaudhuri… - Cancer …, 2019 - Elsevier
Oral cancer is one of the leading cancers in South-Asian countries. Despite the easy access
of the oral cavity, the detection and five year survival rates of OSCC patients are dismal …

Regulation of microRNAs in cancer metastasis

JMC Bouyssou, S Manier, D Huynh, S Issa… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Metastasis is a phenomenon of crucial importance in defining prognosis in patients with
cancer and is often responsible for cancer-related mortality. It is known that several steps are …

Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer

W Su, M Xu, X Chen, N Chen, J Gong, L Nie, L Li, X Li… - Molecular cancer, 2017 - Springer
Background Emerging studies show that long noncoding RNAs (lncRNAs) play important
roles in carcinogenesis and cancer progression. The lncRNA ZEB1 antisense 1 (ZEB1-AS1) …

MicroRNAs and their influence on the ZEB family: mechanistic aspects and therapeutic applications in cancer therapy

M Ashrafizadeh, HL Ang, ER Moghadam… - Biomolecules, 2020 - mdpi.com
Molecular signaling pathways involved in cancer have been intensively studied due to their
crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding …

Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms

A Ameri, HM Ahmed, RDC Pecho, H Arabnozari… - Cancer Cell …, 2023 - Springer
There is a growing interest to understand the role and mechanism of action of microRNAs
(miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that …

MicroRNA regulation of epithelial to mesenchymal transition

ML Abba, N Patil, JH Leupold, H Allgayer - Journal of clinical medicine, 2016 - mdpi.com
Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in
many aspects to several steps of embryonic morphogenesis. In addition to its physiological …