The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The term 'magic bullet'is a scientific concept proposed by the German Nobel laureate Paul
Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease …

The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …

Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in
secretory epithelial cells of airways and intestine. Previous studies provided evidence for a …

Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized
by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide …

Introduction Idiopathic pulmonary fibrosis (IPF), a life-threatening interstitial lung disease, is
characterized by excessive activation and proliferation of fibroblasts and epithelial …

The process of discovering small molecule drugs involves screening numerous compounds
and optimizing the most promising ones, both in vitro and in vivo. However, approximately …

Despite the availability of vaccines and therapeutics, continual genetic alterations render the
severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat …

Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …

Niclosamide and benzbromarone have been described as inhibitors of the calcium activated
chloride channel, TMEM16A, and on this basis have been considered and tested as clinical …