The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Neutrophils are emerging as an important player in skeletal muscle injury and repair.
Neutrophils accumulate in injured tissue, thus releasing inflammatory factors, proteases and …

Bone metabolism is regulated by osteoblasts, osteoclasts, osteocytes, and stem cells.
Pathologies such as osteoporosis, osteoarthritis, osteonecrosis, and traumatic fractures …

The essential role of the neural network in enhancing bone regeneration has often been
overlooked in biomaterial design, leading to delayed or compromised bone healing …

Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain
signals; however, the role of peripheral nerves in tendon injury and repair remains unclear …

Background Diabetic bone defects present significant challenges for individuals with
diabetes. While metformin has been explored for bone regeneration via local delivery, its …

The clinical treatment of critical bone defects presents a great challenge, and distraction
osteogenesis (DO) emerges as a highly effective strategy. However, prolonged …

Achieving optimal implant restoration hinges on both robust osseointegration as the
structural foundation and favorable osseoperception for advanced masticatory function. The …

Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate
vascular and skeletal function. The crosstalk between sympathetic nerves and type H …

Bacterial infection and delayed osteointegration are two major challenges for orthopedic
implants. Surface modification enables the implant have a time-sequenced biological …