Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard
clinical treatment includes chemotherapy, surgical therapy, and radiation therapy …

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …

Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …

Cancer is one of the major causes of mortality worldwide, therefore it is considered a major
health concern. Breast cancer is the most frequent type of cancer which affects women on a …

Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …

Advancing age is a major risk factor for malignant transformation and the development of
cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The …

Bone cancer including primary bone cancer and metastatic bone cancer, remains a
challenge claiming millions of lives and affecting the life quality of survivors. Conventional …

Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA
polymerase-II-based transcription and promotes tumor progression. However, the …

Despite the significant improvement in the survival rate of cancer patients, the total cure of
bone cancer is still a knotty clinical challenge. Traditional surgical resectionof bone tumors is …