Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …

Background There is growing evidence that Alzheimer disease (AD) is a pervasive
metabolic disorder with dysregulation in multiple biochemical pathways underlying its …

Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric
diseases, and that glial cells participate in synapse formation, development, and plasticity …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine
neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B …

Initial biophysical studies on glial cells nearly 50 years ago identified these cells as being
electrically silent. These first studies also demonstrated a large K+ conductance, which led …

Astrocytes, the most numerous glial cells in the brain, play an important role in preserving
normal neural functions and mediating the pathogenesis of neurological disorders. Recent …