Structure and function of multimeric G-quadruplexes

S Kolesnikova, EA Curtis - Molecules, 2019 - mdpi.com
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …

Detection of genomic G-quadruplexes in living cells using a small artificial protein

K Zheng, J Zhang, Y He, J Gong, C Wen… - Nucleic acids …, 2020 - academic.oup.com
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …

Nucleosomes and flipons exchange energy to alter chromatin conformation, the readout of genomic information, and cell fate

A Herbert - Bioessays, 2022 - Wiley Online Library
Alternative non‐B‐DNA conformations formed under physiological conditions by sequences
called flipons include left‐handed Z‐DNA, three‐stranded triplexes, and four‐stranded i …

G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity

J Gong, C Wen, M Tang, R Duan… - Proceedings of the …, 2021 - National Acad Sciences
G-quadruplexes (G4s) formed by guanine-rich nucleic acids play a role in essential
biological processes such as transcription and replication. Besides the> 1.5 million putative …

Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives

X Li, K Zheng, J Zhang, H Liu, Y He… - Proceedings of the …, 2015 - National Acad Sciences
G-quadruplex structures formed by guanine-rich nucleic acids are implicated in essential
physiological and pathological processes and nanodevices. G-quadruplexes are normally …

Destabilization of DNA G-quadruplexes by chemical environment changes during tumor progression facilitates transcription

H Tateishi-Karimata, K Kawauchi… - Journal of the American …, 2017 - ACS Publications
DNA G-quadruplex formation is highly responsive to surrounding conditions, particularly K+
concentration. Malignant cancer cells have a much lower K+ concentration than normal cells …

Evidence that G-quadruplex DNA accumulates in the cytoplasm and participates in stress granule assembly in response to oxidative stress

AK Byrd, BL Zybailov, L Maddukuri, J Gao… - Journal of Biological …, 2016 - ASBMB
Cells engage numerous signaling pathways in response to oxidative stress that together
repair macromolecular damage or direct the cell toward apoptosis. As a result of DNA …

Connexins—therapeutic targets in cancers

M Nalewajska, M Marchelek-Myśliwiec… - International journal of …, 2020 - mdpi.com
Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

The cellular functions and molecular mechanisms of G-quadruplex unwinding helicases in humans

Y Liu, X Zhu, K Wang, B Zhang, S Qiu - Frontiers in Molecular …, 2021 - frontiersin.org
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA
or RNA sequences. They play various regulatory roles in many biological processes. It is …

G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions

H Masai, T Tanaka - Biochemical and biophysical research …, 2020 - Elsevier
G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently
present in the genomes of almost all the biological species. Recent studies reveal roles of G …