Metabolism and colorectal cancer

JC Sedlak, ÖH Yilmaz, J Roper - Annual Review of Pathology …, 2023 - annualreviews.org
Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

The obesity paradox in cancer: a review

H Lennon, M Sperrin, E Badrick, AG Renehan - Current oncology reports, 2016 - Springer
There is a common perception that excess adiposity, commonly approximated by body mass
index (BMI), is associated with reduced cancer survival. A number of studies have emerged …

Leptin signaling in obesity and colorectal cancer

CT Socol, A Chira, MA Martinez-Sanchez… - International journal of …, 2022 - mdpi.com
Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Obesity, diabetes and the risk of colorectal adenoma and cancer

G Soltani, A Poursheikhani, M Yassi… - BMC endocrine …, 2019 - Springer
Background Colorectal cancer (CRC) is the fourth most commonly diagnosed
gastrointestinal (GI) malignancy and the third leading cause of cancer-related death …

The obesity paradox in patients with colorectal cancer: a systematic review and meta-analysis

Y Li, C Li, G Wu, W Yang, X Wang, L Duan… - Nutrition …, 2022 - academic.oup.com
Context Obesity is widely regarded as an established risk factor for colorectal cancer (CRC).
However, recent studies have shown that lower mortality and better cancer-specific survival …

The plausibility of obesity paradox in cancer—point

Y Park, LL Peterson, GA Colditz - Cancer research, 2018 - AACR
In contrast to the convincing evidence that obesity (measured by body mass index, BMI)
increases the risk of many different types of cancer, there is an ambiguity in the role of …

Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: a Global Cancer Update Programme (CUP Global) systematic literature …

G Markozannes, N Becerra‐Tomás… - … journal of cancer, 2024 - Wiley Online Library
Low physical activity and high sedentary behaviour have been clearly linked with colorectal
cancer development, yet data on their potential role in colorectal cancer survival is limited …

[HTML][HTML] Multifaceted effects of obesity on cancer immunotherapies: bridging preclinical models and clinical data

LV Vick, RJ Canter, AM Monjazeb… - Seminars in cancer biology, 2023 - Elsevier
Obesity, defined by excessive body fat, is a highly complex condition affecting numerous
physiological processes, such as metabolism, proliferation, and cellular homeostasis. These …

Anti-obesity drug orlistat alleviates Western-diet-driven colitis-associated colon cancer via inhibition of STAT3 and NF-κB-mediated signaling

BR Jin, HJ Kim, SA Sim, M Lee, HJ An - Cells, 2021 - mdpi.com
Many researchers have argued that Western diet (WD)-induced obesity accelerates
inflammation and that inflammation is a link between obesity and colorectal cancer (CRC) …

The obesity paradox in cancer: clinical insights and perspectives

I Trestini, L Carbognin, C Bonaiuto, G Tortora… - Eating and Weight …, 2018 - Springer
A series of evidence demonstrated that obesity represents an established risk factor for an
increase in the incidence of multiple cancer types and for poor cancer survival …