The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Background The intestinal mucosa is composed of a well-organized epithelium, acting as a
physical barrier to harmful luminal contents, while simultaneously ensuring absorption of …

This study aimed to investigate the protective effect of Herba Origani, the dried whole herb of
Origanum vulgare L., on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice and …

The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative
colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse …

Score Probiotics extracellular vesicles (EVs) have shown potential as EV‐based
nanomaterials therapy for the treatment of inflammatory bowel disease (IBD). Although …

Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial
permeability and intestinal inflammation to assess probiotic intervention as live …

In this study, we prepared a kind of novel microecologics, namely Chinese medicine–
probiotic compound microecological preparation (CPCMP), which is composed of 5 …

The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome
recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger …

Differential microRNA (miRNA or miR) regulation is linked to the development and progress
of many diseases, including inflammatory bowel disease (IBD). It is well-established that …

Aberrant NLRP3 activation has been implicated in the pathogenesis of numerous
inflammation-associated diseases. However, no small molecular inhibitor that directly …