Natural products remain a rich source of new drugs, and the search for bioactive molecules
from nature continues to play an important role in the development of new medicines. Also …

Abstract Introduction The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative
proposes a three-step approach to evaluate proarrhythmogenic liability of drug candidates …

Segmentation of objects with known geometries in an image is a wide research area. In this
paper we show an energy minimization model to detect the tip of glass pipettes in …

This patent relates to a method of detecting in vitro the proarrhythmogenic risk of a drug
candidate performed on human induced pluripotent stem cell-derived cardiomyocytes …

This minireview summarizes the evolution of experimental techniques in cardiomyocyte
electrophysiology over the last 70 years and progressive development of cardiomyocyte …

This chapter highlights various non‐automated classical in vitro techniques used today to
evaluate drug effects on cardiac electrophysiology. It then outlines a three‐pronged …

Segmentation of objects with known geometries in an image is a fundamental research
problem. In this paper we show a three-dimensional energy minimization model to detect the …

Image analysis algorithms and tools have pushed the frontiers of scientific computing in the
last few decades. One of the fields where the modern computer has made a remarkable …

Temperature is an important factor influencing permeation, gating and regulation properties
of ion channels, as well as pharmacological interactions. We developed a multiple ion …

While clinical ECG recordings provide globally integrated records of cardiac electrical
activity from the body surface, it is well recognized that electrical control of cardiac function is …