Identifying parameter regions for multistationarity

C Conradi, E Feliu, M Mincheva… - PLoS computational …, 2017 - journals.plos.org
Mathematical modelling has become an established tool for studying the dynamics of
biological systems. Current applications range from building models that reproduce …

Sign conditions for injectivity of generalized polynomial maps with applications to chemical reaction networks and real algebraic geometry

S Müller, E Feliu, G Regensburger, C Conradi… - Foundations of …, 2016 - Springer
We give necessary and sufficient conditions in terms of sign vectors for the injectivity of
families of polynomial maps with arbitrary real exponents defined on the positive orthant …

A framework for deriving analytic steady states of biochemical reaction networks

BS Hernandez, PVN Lubenia… - PLoS computational …, 2023 - journals.plos.org
The long-term behaviors of biochemical systems are often described by their steady states.
Deriving these states directly for complex networks arising from real-world applications …

Generalized mass action systems: Complex balancing equilibria and sign vectors of the stoichiometric and kinetic-order subspaces

S Muller, G Regensburger - SIAM Journal on Applied Mathematics, 2012 - SIAM
Mass action systems capture chemical reaction networks in homogeneous and dilute
solutions. We suggest a notion of generalized mass action systems that admits arbitrary …

Multistationarity in structured reaction networks

A Dickenstein, MP Millan, A Shiu, X Tang - Bulletin of Mathematical …, 2019 - Springer
Many dynamical systems arising in biology and other areas exhibit multistationarity (two or
more positive steady states with the same conserved quantities). Although deciding …

Atoms of multistationarity in chemical reaction networks

B Joshi, A Shiu - Journal of Mathematical Chemistry, 2013 - Springer
Chemical reaction systems are dynamical systems that arise in chemical engineering and
systems biology. In this work, we consider the question of whether the minimal (in a precise …

The inheritance of nondegenerate multistationarity in chemical reaction networks

M Banaji, C Pantea - SIAM Journal on Applied Mathematics, 2018 - SIAM
We study how the properties of allowing multiple positive nondegenerate equilibria (MPNE)
and multiple positive linearly stable equilibria (MPSE) are inherited in chemical reaction …

Graph-theoretic approaches to injectivity and multiple equilibria in systems of interacting elements

M Banaji, G Craciun - 2009 - projecteuclid.org
We extend previous work on injectivity in chemical reaction networks to general interaction
networks. Matrix-and graph-theoretic conditions for injectivity of these systems are …

Some results on injectivity and multistationarity in chemical reaction networks

M Banaji, C Pantea - SIAM Journal on Applied Dynamical Systems, 2016 - SIAM
The goal of this paper is to gather and develop some necessary and sufficient criteria for
injectivity and multistationarity in vector fields associated with a chemical reaction network …

The kinetic space of multistationarity in dual phosphorylation

E Feliu, N Kaihnsa, T de Wolff, O Yürük - Journal of Dynamics and …, 2022 - Springer
Multistationarity in molecular systems underlies switch-like responses in cellular decision
making. Determining whether and when a system displays multistationarity is in general a …