The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …

Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Recent studies highlight the implication of innate and adaptive immunity in the
pathophysiology of Alzheimer's disease, and foster immunotherapy as a promising strategy …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …